Fetal Growth

Eighth International Conference on

Fetal Growth

Berlin, Germany

9 - 11 October 2019

Scientific Programme

Wednesday 9 October
Workshops Thursday 10 October
Conference Day 1 Friday 11 October
Conference Day 2 Poster-Oral
Presentations Electronic
Posters

Pre-Conference Workshops
Faculty
Prof Jason Gardosi & Mandy Williams – Perinatal Institute, UK
Prof Francesc Figueras – University of Barcelona, Spain
Prof Ahmet Baschat – Johns Hopkins University, USA
Prof Torvid Kiserud - University of Bergen, Norway

09:00 – 17:00	Fetal Growth Assessment
09:00	Screening and Surveillance
	• Evidence based risk assessment • Standardised measurement • Customised growth charts • Audit tools; quality assurance
12:30	Lunch
		13:30 – 17:00 Workshop für Hebammen:
13:30	Ultrasound and Doppler	Individuelle Wachstumskurven (GROW) und das Growth Assessment Protocol (GAP)
	• Ultrasound biometry • Liquor, biophysical profile • Doppler parameters – basic • Doppler parameters - advanced	• Einflüsse individueller Merkmale auf fetales Wachstum • Screeningmöglichkeiten: äußere Untersuchungen und Messungen • Anwendung des GAP-Tools in der Praxis; Qualitätssicherung • Implementierungsmöglichkeiten in Deutschland
17:00	Close

18:00 - 20:00	Welcome Reception

Presentations: K=Keynote (20 min) O=Oral (10 min) PO=Poster-Oral (3 min) D=Discussion

09:00			Welcome
09:10	Session 1		Intrauterine growth: outcomes for mother and infant
K	Birgit Arabin	DE	Effect of pregnancy with growth disorders on long-term health of mothers and offspring
O	Kasia Maksym	UK	Maternal stress, anxiety and depression in severe fetal growth restriction
O	Ahmet Baschat	US	Transition to neonatal life in the growth restricted fetus – what do we need to tell our neonatology colleagues?
O	Gernot Desoye	AT	A reduction in sedentary behaviour in obese women reduces neonatal adiposity: the Dali randomized trial
O	Jezid Miranda	ES	SGA and LGA newborns have increased mortality risk during the first year of life: a cohort analysis of 10 years of live births in the United States
PO	Pradeep Alur	US	Sex differences in transition phase of nutrition in ELBW infants
PO	Edurne Mazarico	ES	Neonatal mortality and morbidity of extreme premature neonates with growth restriction
D	Panel		Barriers for prevention of adverse outcome
P	Posters - see list		Brief introduction by authors
10:20	Refreshment Break
10:40	Session 2		Associations and risk factors
O	Lesley McCowan	NZ	Folic acid supplementation is associated with size at birth in the screening for pregnancy endpoints study
O	Lynn Sadler	NZ	How might smoking help us to understand the causes of fetal growth restriction?
PO	Helen Baston	UK	Engaging pregnant smokers with smoking cessation services: offering carbon monoxide self-monitoring
O	Maria Dolores Gomez Roig	ES	Heavy metal levels in placenta in fetuses with FGR and AGA
O	Jezid Miranda	ES	Human fetal growth restriction is influenced mainly by maternal socioeconomic status: an ecological study within a city from a developing country
PO	Catarina Palma dos Reis	PT	Outcomes of fetal growth restriction: does maternal age matter?
D	Panel		Risk factors: screening and prevention
11:40	Session 3		Diabetes in pregnancy
K	Suresh Seshadri	IN	Diabetes and fetal growth: pre-gestational and GDM; role of diabetic control; roles and limitations of Doppler
O	Torvid Kiserud	NO	Diabetes mellitus: pathophysiological background for increased risk of fetal demise in late pregnancy
PO	Tamal Datta	UK	Outcome of large for gestational age fetuses in non-diabetic mothers
PO	Tracy Tomlinson	US	Beyond carbohydrates: the association between fat consumption and fetal overgrowth with type 1 diabetes
D	Panel		Diabetes and fetal growth
12:40	Lunch
13:30	Session 4		Fetal growth, size and standards for measurement
O	Francesc Figueras	ES	Fetal size vs growth in predicting outcome
O	Torvid Kiserud	NO	Physiological fetal growth retardation; the WHO fetal growth study
O	Jason Gardosi	UK	Slow growth defined by customised growth trajectory and adverse perinatal outcome
D	Panel		Shall we primarily rely on fetal size or fetal growth?
O	Lesley McCowan	NZ	Risk of stillbirth at term associated with small (SGA) and large (LGA) for gestational age by customised, World Health Organisation (WHO) and Intergrowth 21 (IG-21) birthweight centiles
O	Jezid Miranda	ES	Intergrowth¬21 vs. WHO fetal growth charts for the identification of SGA in a population from Latin America
O	Anna Kajdy	PO	Comparison of population vs. customised birthweight charts in Poland for the prediction of neonatal outcome
O	Urszula Sarzynska-Nowacka	PO	Predictive accuracy of customized versus populational twin growth chart for adverse perinatal outcome: a cohort study
PO	Oliver Hugh	UK	Perinatal mortality and SGA rate according to Hadlock and customised fetal weight standards in a South Asian population
PO	Oliver Hugh	UK	Customised vs population based fetal weight standards to define small for gestational age at 22 weeks gestation
PO	Judit Martinez	ES	Accuracy of Hadlock and Intergrowth formulae for birthweight in pregnancies with suspected late IUGR
PO	Marta Rial-Crestelo	ES	Prescriptive reference standards of third-trimester cerebroplacental ratio and its physiological determinants
D	Panel		Which standards should be used?
15:40	Refreshment Break
16:00	Session 5		Antenatal detection of FGR: current strategies
O	Gabrijela Brzan Simenc	SL	Small-for-gestational age neonate: What is the benefit of antenatal detection?
O	Glenn Gardener	AU	Improving the detection of fetal growth restriction: evaluation of user experience of an interactive educational program
O	Kristen Gibbons	AU	Investigating the utility of the customised fetal growth chart: a randomised controlled trial
O	Jason Gardosi	UK	Improved detection of SGA and reduction of stillbirths in England
O	Oliver Hugh	UK	Effect of serial scanning in high risk pregnancy on risk of stillbirth
O	Nuzhat Aziz	IN	Implementing comprehensive fetal growth surveillance: GAP India
O	Joyce Cowan	NZ	The Growth Assessment Protocol (GAP) increased detection of Small for Gestational Age (SGA) babies and reduced neonatal morbidity at New Zealand tertiary maternity hospital
O	Robin Hughes	UK	GAP protocol – reducing stillbirths through improved identification of FGR – the Hull experience
POs	Poster Orals 10 to 21		See list
D	Panel		Challenges and progress in implementation
18:00	Close

20:00	Gala Dinner & Dance

Presentations: K=Keynote (20 min) O=Oral (10 min) PO=Poster-Oral (3 min) D=Discussion

08:30			Welcome
08:40	Session 6		Hypertension, fetal growth and markers of angiogenesis
K	Roger Newman	US	Fetal growth in hypertensive pregnancy: the NIH studies
O	Lisa Droege	DE	Placental weight in preeclamptic and growth-restricted pregnancies in correlation to the maternal sFlt-1/PlGF serum concentration and Doppler findings
O	Marek Lubusky	CZ	Maternal serum levels of sFlt-1 and PlGF in a low-risk population of pregnant women in predicting pre-eclampsia, fetal growth restriction and newborn SGA
O	Manel Mendoza	ES	Maternal and perinatal outcomes in growth restricted fetuses with extremely high sFlt-1/PlGF ratio
O	Manel Mendoza	ES	Prediction of elective delivery in SGA and FGR
PO	Magdalena Bednarek-Jędrzejek	PO	Angiogenesis markers in ultrasound-confirmed late-onset fetal growth restriction, and their utility in determining the neonatal outcome
PO	Tania Meneses	PT	sFlT1-PlGF ratio in early vs. late FGR
D	Panel		Role of markers in screening and surveillance
10:00	Refreshment Break
10.20	Session 7		Ultrasound and Doppler: new insights for management
K	Ahmet Baschat	US	Planning surveillance intervals and timing delivery in early onset IUGR
K	Francesc Figueras	ES	Planning surveillance intervals and timing delivery in late onset IUGR
PO	Andrew Sharp	UK	Pregnancy outcomes with raised umbilical artery doppler pulsatility index identified before 32 weeks gestation
O	Jose Morales Rosello	ES	Outcome predictors of spontaneous and induced labour in fetuses examined up to 34 weeks: a multivariable analysis study
O	Tracy Tomlinson	UK	Prediction of severe adverse perinatal outcomes in pregnancies complicated by fetal growth restriction
K	Giuseppe Rizzo	IT	Umbilical vein flow predicts adverse perinatal outcome in late fetal growth retardation
K	Greggory DeVore	US	Third trimester ultrasound assessment of cardiac function in the detection and management of FGR
PO	Tanja Groten	DE	Cardiac dysfunction in fetal growth retardation measured by means of myocardial performance index
D	Panel		Is there consensus on management, based on current evidence?
12:30	Lunch
13:20	Session 8		Prevention and treatment
O	Kasia Maksym	UK	Do we need treatment for severe early onset intrauterine growth restriction: Update on EVERREST Project
O	Anna David	UK	Classifying adverse events in early onset FGR to develop a clinical trial dose-escalation plan
O	Uwe Schneider	DE	The relation between perinatal outcome and the diagnostic criteria of late fetal growth restriction
PO	Tanja Groten	DE	Pentaerithrityl tetranitrate (PETN) for secondary prevention of fetal growth restriction (PETN-Trial)
O	Manouk Hendrix	NL	Maternal vascular malformation in the placenta is an indicator for fetal growth restriction irrespective of neonatal birthweight
O	Francesca Parisi	IT	Impact of human embryonic morphological development on fetal growth parameters: the Rotterdam periconceptional cohort (PREDICT Study)
O	Jezid Miranda	ES	Identification of phenotypes of FGR using a network-based clustering approach
POs	Poster Orals 28 to 30		See list
14:30	Session 9		Management guidelines: putting evidence into practice
K	Lesley McCowan	NZ	International review of guidelines
R	Roundtable		National guidelines for fetal growth surveillance and management: Dietmar Schlembach - DE; Giuseppe Rizzo - IT; Roger Newman - USA; Jason Gardosi - UK
D	Panel		General Discussion
15:40	Refreshment Break
16:00	Session 10		Clinical case scenarios
	Faculty		Interactive presentations and discussion
			Summary of take home messages
17:15	Best abstracts		Prizes & Presentations

17:30	Close

18:45	Berlin Festival of Lights - Walk to Brandenburg Gate

PO=Poster-Oral Presentation (3 min)

	Author		Title
Session 1
PO 1	Pradeep Alur	US	Sex differences in transition phase of nutrition in ELBW infants
PO 2	Edurne Mazarico	ES	Neonatal mortality and morbidity of extreme premature neonates with growth restriction
Session 2
PO 3	Helen Baston	UK	Engaging pregnant smokers with smoking cessation services: offering carbon monoxide self-monitoring
PO 4	Catarina Palma dos Reis	PT	Outcomes of fetal growth restriction: does maternal age matter?
Session 3
PO 5	Tamal Datta	UK	Outcome of large for gestational age fetus in non-diabetic mothers
PO 6	Tracy Tomlinson	US	Beyond carbohydrates: the association between fat consumption and fetal overgrowth with type 1 diabetes
Session 4
PO 7	Oliver Hugh	UK	Customised vs population based fetal weight standards to define small for gestational age at 22 weeks gestation
PO 8	Oliver Hugh	UK	Perinatal mortality and SGA rate according to Hadlock and customised fetal weight standards in a South Asian population
PO 9	Judit Martinez	ES	Accuracy of Hadlock and INTERGROWTH formula for birthweight in pregnancies with suspected late IUGR
PO 24	Marta Rial-Crestelo	ES	Prescriptive reference standards of third-trimester cerebroplacental ratio and its physiological determinants
Session 5
PO 10	Lucy Armatage	UK	Impact of customised growth charts in a tertiary hospital – local data for shared decision making
PO 11	Anagha Chirdrawar	UK	Audit of missed small for gestational age babies - does implementation of GAP training make a difference?
PO 12	Anna Kajdy	PO	Fetal growth diagnosis and management among obstetric and neonatal medical professionals - preliminary results of a survey of practice
PO 13	Annie Burrin	UK	Effect of implementation of GAP in Cardiff, Wales
PO 14	Badenan Fathulla	UK	Audit for detection of small-for-gestational-age babies at Royal Free Hospital using Growth Assessment Protocol
PO 15	Eziamaka Ezenkwele	NG	Obstetric risk factors for stillbirths in University of Nigeria Teaching Hospital (UNTH), Enugu
PO 16	Heather Watson	UK	Treasure hunting - the midwife-led fetal growth assessment (MFGA) clinic to identify the high risk fetus in the low-risk pregnancy
PO 17	Katarzyna Kosińska-Kaczyńska	PO	The knowledge and experiences of pregnant women regarding physical activity during pregnancy
PO 18	Jothilakshmi Nallathambi	UK	Detection of small for gestational age fetuses in a district general hospital
PO 19	Priti Wuppalapati	UK	Antenatal corticosteroid administration prior to elective caesarean section in diabetic women between 37 to 38+6 weeks gestation - more harm than good?
PO 20	Saudabi Valappil	AE	Placenta clinic approach to screening for placental insufficiency
PO 21	Sian Bullough	UK	The intrapartum impact of failure to identify the SGA fetus prior to induction of labour
Session 6
PO 22	Magdalena Bednarek-Jędrzejek	PO	Angiogenesis markers in ultrasound - confirmed late onset fetal growth restriction and their utility in determining the neonatal outcome
PO 23	Tania Meneses	PT	SFlT1-PLGF ratio in early vs late FGR
Session 7
PO 25	Andrew Sharp	UK	Pregnancy outcomes with raised umbilical artery doppler pulsatility index identified before 32 weeks gestation
PO 26	Tanja Groten	DE	Cardiac dysfunction in fetal growth retardation measured by means of myocardial performance index
Session 8
PO 27	Tanja Groten	DE	Pentaerithrityl tetranitrate (PETN) for secondary prevention of fetal growth restriction (PETN-trial)
PO 28	Gabriela Loscalzo	ES	MicroRNA-148B-3P and MicroRNA-25-3P are overexpressed in fetuses with late-onset fetal growth restriction
PO 29	Katarzyna Kosinka-Kaczynska	PO	Low first trimester PAPP-A does not predict intrauterine growth restriction in twins
PO 30	Paz Ahumada	ES	Risk of C-section and neonatal intensive care unit admission in FGR clinical subtypes: IUGR type I and SGA foetuses

Electronic posters will be briefly introduced in Session 1 and will be on display throughout the conference

	Author		Title
P 1	Andreja Trojner Bregar	SL	Have tall pregnant women heavy babies?
P 2	Andrew Sharp	UK	A rare case of extensive fetal intracranial haemorrhage in an early onset FGR infant
P 4	I.S. Kozlovskaia	RU	Causes of late miscarriages
P 5	I.S. Kozlovskaia	RU	Causes of late miscarriages in multiple pregnancies
P 6	Iwona Szymusik	PO	Neonatal outcomes of smaller twins in cases of birthweight discordance
P 7	Jan Modzelewski	PO	Comparison of detection rates using different growth charts
P 8	Katarzyna Kosińska-Kaczyńska	PO	Trends, attitude and knowledge about the methods of labour pain management among polish women
P 9	Saudabi Valappil	AE	Perinatal outcome in early onset fetal growth restriction - single centre experience
P 10	Sharon Fan	UK	Preventing fetal growth restriction and other adverse outcomes in women with low PAPP-A: are we, in Hull, doing too much or not enough?